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At physiological concentrations, ROS is important to cellular division, but excessive ROS leads to stressed damages to protein, DNA and lipid (Szczepanowska et al., 2012

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Ueda S, Yamagishi SI, Matsumoto Y, Fukami K, Okuda S (2007) Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease

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Conclusion: There is no evidence from the ENCHANTED trial suggesting that lower dose of alteplase improves outcomes in patients with AIS patients and CMBs